Bioavailability of Lesinurad and Intravenous [14C]Lesinurad

Exclusion Criteria

• - Subject has a history or suspicion of kidney stones.
• - Subject has undergone major surgery within 3 months prior to Screening.
• - Subject donated blood or experienced significant blood loss (>450 mL) within 12 weeks prior to Screening or gave a plasma donation within 4 weeks prior to Screening.
• - Subject has inadequate venous access or unsuitable veins for repeated venipuncture.
• - Subject does not have a normal or clinically acceptable physical examination, per the Investigator’s judgment.
• - Subject has clinically relevant abnormalities in blood pressure, heart rate, or body temperature, per the Investigator’s judgment.
• - Subject has Screening clinical safety laboratory parameters (serum chemistry, hematology, or urinalysis) that are outside the normal limits and are considered clinically significant by the Investigator.
• - Subject has clinically relevant abnormalities in 12-lead electrocardiogram, per the Investigator’s judgment.
• - Subject has a Screening serum urate level > 7 mg/dL.
• - Subject had radiation exposure that exceeds 5 mSv in the last 12 months or 10 mSv in the last 5 years. This includes radiation exposure from the present study or other clinical studies, including diagnostic X-rays and other medical exposures but excluding exposure to background radiation. No occupationally exposed worker, as defined in the Ionising Radiation Regulations 1999, shall participate in the study.