Characterization of the Kinetics of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and in Subjects with Type 2 Diabetes Mellitus (T2DM)

Inclusion Criteria

• Inclusion criteria for T2DM
• - Diagnosis of T2DM
• - Must be on one of the following therapies: diet therapy alone, diet plus a sulfonylurea, diet plus metformin, or diet plus sulfonylurea plus metformin
• - Subjects taking metformin, and/or sulfonylurea must be on a stable dose for at least 2 months prior to study drug administration
• - Must have a fasting plasma glucose concentration ≤ 200 mg/dl, and HbA1C ≤ 10%
• Inclusion criteria for healthy subjects:
• - Healthy subjects (as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations)
• - Subjects with (eGFR ≥ 60 and ≤ 160 mL/min/1.73m² and urinary albumin excretion < 300 mg/g creatinine)
• - Body Mass Index (BMI) of 18 to 38 kg/m²
• - Men and women, ages 18 to 65 years, inclusive
• Exclusion criteria for all subjects:
• - Subjects with Type 1 Diabetes or uncontrolled Type 2 Diabetes Mellitus
• - Subjects with T2DM with fasting plasma glucose > 200 mg/dL, healthy subjects with fasting plasma glucose > 105 mg/dL
• - Subjects with T2DM with HbA1C > 10.0%, healthy subjects with HbA1C > 6.8%