A study of exercise endurance and lung hyperinflation in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria

• Inclusion Criteria:
• - A diagnosis of stable moderate to severe COPD (GOLD 2006); post-levalbuterol FEV1 >=30% and < 80% predicted and FEV1/FVC<70% predicted
• - Current or former cigarette smoker
• - Functional Residual Capacity (FRC) measured by body plethysmography >= 120% of predicted value
• - Baseline Dyspnea Index (BDI) focal score ≤ 7 at Visit 4
• Exclusion Criteria:
• - History of presence of asthma, allergic rhinitis, or atopy
• - Hospitalization for acute COPD exacerbation in the 3 months prior to study entry
• - Respiratory tract infection (including the upper respiratory tract) or COPD exacerbation in the 6 weeks prior to study entry
• - Clinically significant respiratory conditions other than COPD
• - Chronic use of oxygen therapy >= 15 hours a day