Study of AZD0754 in Participants with Metastatic Prostate Cancer - APOLLO

Exclusion Criteria

• 1 Participants with weight less than 39 kg
• 2 History of another primary malignancy except for malignancy treated with curative intent with no known active disease (≥ 2 years) before the first dose of study intervention and of low potential risk for recurrence. Such exceptions include non-melanoma cancer of the skin that has undergone curative therapy or adequately treated carcinoma in situ without evidence of disease.
• 3 Participants with known brain metastases.
• 4 Prior solid organ transplantation.
• 5 Active or prior documented autoimmune or inflammatory disorders (including but not limited to inflammatory bowel disease [eg, colitis, Crohn’s disease], diverticulitis, systemic lupus erythematosus, Wegener’s syndrome, myasthenia gravis, Graves’ disease, rheumatoid arthritis, hypophysitis, uveitis, autoimmune pneumonitis, autoimmune nephritis, or nephropathy, etc). The following are exceptions to this criterion:
• (a) Participants with vitiligo or autoimmune alopecia.
• (b) Participants with autoimmune hypothyroidism (eg, following Hashimoto thyroiditis) stable on hormone replacement.
• (c) Any chronic inflammatory or autoimmune skin condition that does not require systemic therapy.
• (d) Participants without active disease in the last 5 years may be included, but only after consultation with the Sponsor.
• (e) Participants with coeliac disease controlled by diet alone.
• 6 Stroke, intracranial haemorrhage, or seizure within 6 months of apheresis.
• 7 Cardiac arrhythmias, (such as multifocal premature ventricular contractions, bigeminy, trigeminy, ventricular tachycardia), which are symptomatic or require treatment (Common Terminology Criteria for Adverse Events [CTCAE] Grade 3) unless controlled by pacemaker (discussion with the Study Physician required); symptomatic or uncontrolled atrial fibrillation despite treatment, or asymptomatic sustained ventricular tachycardia.
• 8 Investigator judgement of one or more of the following:
• (a) Mean resting corrected QT interval > 470 ms, obtained from triplicate electrocardiograms (ECGs) performed at screening.
• (b) History of QT prolongation associated with other medications that required discontinuation of that medication, or any current concomitant medication known to prolong the QT interval.
• (c) Congenital long QT syndrome, family history of long QT syndrome, or unexplained sudden death under 40 years of age in first–degree relatives.
• 9 Uncontrolled intercurrent illness including, but not limited to, ongoing or active known infection, cardiomyopathy of any aetiology, symptomatic congestive heart failure defined by New York Heart Association class ≥ 3), interstitial lung disease, uncontrolled hypertension, uncontrolled diabetes mellitus, unstable angina pectoris, history of myocardial infarction within the past 6 months prior to apheresis.
• 10 Active, uncontrolled epilepsy. Participants without active/uncontrolled epilepsy in the last 5 years may be included.
• 11 Persistent toxicities (CTCAE Grade ≥ 2) caused by previous anticancer therapy, excluding alopecia. Participants with irreversible toxicity that is not reasonably expected to be exacerbated by study intervention may be included (eg, hearing loss) after consultation with the Study Physician or Medical Monitor. Participants with Grade 2 neuropathy will be evaluated on a case-by-case basis after consultation with the Study Physician or Medical Monitor.
• 12 Seropositive for human immunodeficiency virus (HIV).
• 13 Active hepatitis C infection (HCV). Participants testing positive for HCV antibody are eligible only if the polymerase chain reaction is negative for HCV RNA.
• 14 Participants with hepatitis B virus (HBV) may be included under the following circumstances:
• (a) Negative for hepatitis B surface antigen (HbsAg) and positive for anti-HBc antibody
• (b) Positive for HbsAg, but for > 6 months have had normal transaminases and HBV DNA levels between 0 – 2000 IU/mL (inactive carrier state) and willing to start and maintain antiviral treatment for at least the duration of the study.
• (c) HBV DNA levels > 2000 IU/mL but on prophylactic antiviral treatment for the past 3 months and will maintain the antiviral treatment during the study.
• 15 Local requirements for the testing for infectious diseases and exclusions of applicable participants should be followed per local regulations.
• Prior/Concomitant Therapy
• 16 Participants may not receive full-dose long-acting oral (eg, warfarin) or parenteral anticoagulants or thrombolytic agents for therapeutic (as opposed to prophylactic) purpose from the time of informed consent to 28-days post infusion of AZD0754. Use of short acting direct oral anticoagulants (eg, rivaroxaban) for therapeutic and prophylactic purposes are permitted.
• 17 Received the following:
• (a) Major surgery within 2 weeks prior to apheresis, or planned major surgery within 4 weeks of the study treatment administration (Note: participants with planned surgical procedures to be conducted under local anaesthesia may participate after discussion with the Sponsor).
• (b) Steroids (except inhaled steroids) or other immunomodulators (including interleukins, interferons, and thymosins) of systemic therapeutic dose, and systemic corticosteroids at doses exceeding 10 mg/day of prednisone or equivalent < 7 days prior to apheresis.
• 18 Receipt of the last dose of anticancer therapy (chemotherapy, immunotherapy, endocrine therapy targeted therapy, biologic therapy, tumour embolisation, or monoclonal antibodies, investigational product) within 5 half-lives or ≤ 21 days (whichever is shorter) prior to apheresis. Radiotherapy within 14 days. However, if the radiation portal covered ≤ 5% of the bone marrow reserve, the participant is eligible irrespective of the end date of radiotherapy. If sufficient washout time has not occurred due to the schedule or PK properties of an agent, a longer washout period will be required, as agreed by AstraZeneca and the Investigator.
• 19 Any concurrent anticancer treatment with the following exceptions:
• (a) Protocol-defined LDC
• (b) Hormonal therapy for non cancer-related conditions (eg, hormone replacement therapy)
• (c) Androgen deprivation therapy with a luteinising-hormone replacement hormone agonist/antagonist is required if needed to maintain testosterone level in the castration range (levels < 50 ng/dL) and should be continued (unless bilateral orchiectomy) throughout the trial. Following apheresis, bridging therapy is permitted (if required) as outlined in Section 6.1.2
• 20 Participants should not have received any live vaccines within 30 days prior to apheresis. Participants can receive coronavirus (COVID)-19 vaccines, at the discretion of the Investigator, following a benefit/risk evaluation for the individual participant and in accordance with local rules and regulations and vaccination guidelines. Note: If a COVID-19 vaccine is administered, it should ideally be done at least one week prior to LDC or after completion of the DLT period.
• Prior/Concurrent Clinical Study Experience
• 21 Prior treatment with a CAR-T therapy directed at any target or any therapy that is targeted to STEAP2.
• 22 Participants with a known life-threatening allergy, hypersensitivity, or intolerance to AZD0754 or any of the excipients of the product, including dimethylsulfoxide.
• In addition to the above, the following exclusion criteria is applicable for study participants in Australia:
• - Participants with human T-lymphotropic virus (HTLV).