A study to investigate how AZD4144 affects the pharmacokinetics of rosuvastatin in healthy participants

Exclusion Criteria

• -History of any clinically important disease or disorder which, in the opinion of the Investigator, may either put the participant at risk because of participation in the study, or influence the results or the participant’s ability to participate in the study.
• -Clinically significant serious active and chronic infections within 60 days prior to randomisation.
• -History or presence of gastrointestinal, hepatic, or renal disease or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.
• -Any clinically important illness, medical/surgical procedure, or trauma within 4 weeks of the randomisation.
• -Active systemic bacterial, viral, or fungal infection within 14 days prior to dosing or presence of fever (confirmed tympanic body temperature > 37.5 °C) within 14 days prior to dosing on Day 1 depending on experienced symptoms.
• -Bacillus Calmette-Guérin vaccine within one year prior to signing the ICF.
• -Any laboratory values with deviations at the Screening Visit or on admission to the Clinical Unit. Abnormal values may be repeated at the discretion of the Investigator: alanine transaminase (ALT) >1.00 × Upper Limit Normal (ULN), aspartate transaminase (AST) > 1.00 ×ULN, white blood cell count < Lower limit normal (LLN), differential neutrophils < LLN, bilirubin > 1.00 × ULN, eGlomerular filtration rate (eGFR) < 60 mL/min/1.73 m² calculated using the Chronic Kidney Disease Epidemiology Collaboration equation (eGFR will only be assessed at Screening).
• -Any positive result at Screening for serum hepatitis B surface antigen, hepatitis B core antibody, hepatitis C antibody, or human immunodeficiency virus.
• -Has received any investigational medicinal product.
• -Participants who have previously received AZD4144.
• -Participants with myopathy, defined as muscle weakness that in opinion of the investigator, enhances the participant's risk of developing statin-associated muscle symptoms