Study to investigate safety, tolerability and effect of multiple dosing with AZD 4721 and/or with AZD 5069

Exclusion Criteria

• 1. Pyrexial with a body temperature higher than 37.7°C at Day -1 (Visit 2), or as judged by the investigator.
• 2.Screening blood neutrophil counts (taken in the morning) not within the laboratory reference range (Visit 1).
• 3. Other latent or chronic infections (eg, recurrent sinusitis, genital or ocular herpes, urinary tract infection) or at risk of infection (surgery, trauma, or significant infection) in the previous 90 days, or history of skin abscesses within the previous 90 days.
• 4.Clinically significant lower respiratory tract infection not resolved within 4 weeks prior to screening (Visit 1), as determined by the investigator.