Study identifier:D5130C00076
ClinicalTrials.gov identifier:N/A
EudraCT identifier:N/A
CTIS identifier:N/A
An open-label, randomised, 3-period, 3-treatment, crossover, single-centre, single-dose, bioavailability study with alternative methods of administration of crushed ticagrelor tablets, 90 mg, compared to whole ticagrelor tablets, 90 mg, in healthy volunteer
Bioavailability Heathy volunteers
Phase 1
Yes
Ticagrelor 90 mg whole tablet, Ticagrelor 90 mg tablet crushed, Dispersed ticagrelor 90 mg tablet suspended in water - nasogastric tube
All
36
Interventional
18 Years - 50 Years
Allocation: Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Verified 01 Dec 2014 by AstraZeneca
AstraZeneca
-
No locations available
Arms | Assigned Interventions |
---|---|
Experimental: A Ticagrelor 90 mg as a whole tablet | Drug: Ticagrelor 90 mg whole tablet Ticagrelor 90 mg whole tablet administered as a single oral dose |
Experimental: B Ticagrelor 90 mg tablet crushed and suspended in water | Drug: Ticagrelor 90 mg tablet crushed Ticagrelor 90 mg crushed and suspended in water |
Experimental: C Dispersed ticagrelor 90 mg tablet suspended in water and administered through a nasogastric tube into the the stomach | Drug: Dispersed ticagrelor 90 mg tablet suspended in water - nasogastric tube Dispersed 90 mg ticagrelor 90 mg tablet suspended in water and administered through a nasogastric tube into the stomach |