Effects of administration of fostamatinib on blood concentrations of digoxin in healthy subjects

Exclusion Criteria

• - History or presence of gastrointestinal, hepatic, or renal disease or any other condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs (except for cholecystectomy)
• - Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of the investigational product
• - Subjects who smoke more than 5 cigarettes or the equivalent in tobacco per day
• - Absolute neutrophil count of <2500/mm3 or 2.5 x 109/L
• - Previous treatment with fostamatinib or digoxin in the present study