Assessing the pharmacokinetics of NKTR-118 in subjects with renal impairment compared to that in subjects with normal renal function

Inclusion Criteria

• - Provision of signed written and dated informed consent prior to any study specific procedures.
• - Male or female volunteers aged 18 to 80 years (inclusive) having normal renal function, or suffering from moderate or severe renal impairment or ESRD.
• Male subjects who are sexually active must be willing to use a barrier method of contraception (condom). Women must be of non-childbearing potential or, if of childbearing potential, must have a negative pregnancy test (at screening and at each admission) and be using a highly effective form of birth control for 3 months before enrollment and be willing to use a highly effective form of birth control during the study and until 3 months after their last dose of IP.
• - Have a BMI between 18 and 40 kg/m2 (inclusive) and weigh at least 50 kg.
• - Subjects must be able to understand and to comply with study procedures, restrictions and requirements.