Study to assess effect of device and formulation on Pharmacokinetics (PK) of AZD1402

Exclusion Criteria

• 1.Subjects who have a significant history of recurrent or ongoing 'dry eye syndrome' of any cause that may be chronic or acute, that may affect the interpretation of safety data associated with the potential for anti-drug antibodies targeted to AZD1402 (structurally related to Tlc).
• 2.History or clinical manifestations of any clinically significant medical disorder that, in the opinion of the Investigator, may put the subject at risk because of participation in the study, influence the results of the
• study or affect the subject's ability to participate in the study.
• 3.History or presence of gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.
• 4.Any clinically significant illness, infection, medical/ surgical procedure, or trauma within 4 weeks of Day 1 of Treatment Period 1, or planned inpatient surgery or hospitalization during the study period.
• 5.Any clinically significant abnormalities in clinical chemistry, hematology, or urinalysis results, at the Screening Visit and/or on Day - 1 of Treatment Period 1, as judged by the PI.
• 6.Any clinically significant abnormal findings in vital signs at the Screening Visit and/or on Day -1 of Treatment Period 1, as judged by the PI.
• 7.Any clinically significant abnormalities on 12-lead ECG at the Screening Visit., as judged by the PI.
• 8.History of, or known significant infection including helminth, hepatitis A, B, or C, HIV, TB (i.e., positive result for interferon (INF) gamma release assay (IGRA), QuantiFERON TB-Gold), that may put the subject at risk during participation in the study.
• 9.Subjects with history of latent or active TB.
• 10.Subjects with any history of malignancy or neoplastic disease.
• 11.Subjects with a disease history suggesting abnormal immune function.
• 12.History of anaphylaxis following any biologic therapy and known history of allergy or reaction to any component of the investigational product formulation.
• 13.Subjects who are not able to perform correct spirometry tests at the Screening Visit.
• 14.Subjects with a forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) < 80% of the predicted (calculated) values and FEV1/FVC ratio < 0.7 in pulmonary function test (spirometry)
• at the Screening Visit.
• 15.Males who are sexually active with a female partner of childbearing potential and who have not had a vasectomy and who do not agree to comply with highly effective methods of contraception from Day 1 of
• Treatment Period 1 until 90 days after the last dose of IMP.
• 16.Participation in any clinical study for new chemical entity within the previous 16 weeks or a marketed drug clinical study within the previous 12 weeks or within 5
• half-lives whichever is the longer before the first dose of study drug.
• Note: subjects consented and screened, but not randomized in this study
• or a previous phase I study, are not excluded.
• 17.Known or suspected history of drug abuse in the last 5 years
• 18.Known or suspected history of alcohol abuse or excessive intake of alcohol in the last 2 years
• 19.Current smokers or those who have smoked or used nicotine products (including e-cigarettes) within the 3 months prior to the Screening Visit.
• 20.Positive screen for drugs of abuse, alcohol or cotinine at the Screening Visit or on each admission to Clinical Unit.
• 21.Plasma donation within 1 month of screening or any blood donation/loss more than 450 mL during the 3 months prior to the Screening Visit.
• 22.Subjects who have received live or attenuated vaccine in the 4 weeks prior to Day 1 of Treatment Period 1.
• 23.Use of any prescribed or non-prescribed medication including antacids, herbal remedies, megadose vitamins and minerals during the 2 weeks prior to the first administration of IMP or within 5 half-lives whichever is the longer before the first dose of study drug.
• 24.Involvement of any AstraZeneca, PAREXEL or study site employee or their close relatives
• 25.Subjects who have previously received AZD1402.
• 26.Judgment by the PI that the subject should not participate in the study if they have any ongoing or recent (i.e., during the screening period) minor medical complaints that may interfere with the interpretation of study data or are considered unlikely to comply with study procedures, restrictions, and requirements.
• 27. Inability to communicate well with the Investigator (i.e., language problem, poor mental development or impaired cerebral function).
• 28. Vulnerable subjects, e.g., kept in detention, protected adults under guardianship, trusteeship, or committed to an institution by governmental or juridical order. In addition, the following is considered a criterion for the exclusion from the optional genetic component of the study
• 29. Non-leukocyte depleted whole blood transfusion within 120 days of the date of the genetic sample collection or previous bone marrow transplant.