DIabetic Retinopathy Candesartan Trials - DIRECT

Exclusion Criteria

• - Patients with the following conditions are excluded from participation in the study:
• - Cataract or media opacity of a degree which precludes taking gradable retinal photographs
• - Angle closure glaucoma, which precludes pharmacological dilatation of the pupil
• - History of or presence of proliferative retinopathy
• - History or presence of clinical significant macular oedema (CSME)
• - History or evidence of photocoagulation of the retina
• - Other retinal conditions which may mask assessment, eg, retinal vein occlusion
• - Positive micral dipstick test
• - Presence of secondary diabetes
• - Pregnant or lactating women or women of child bearing potential not practicing an adequate method of contraception
• - Need of treatment with ACE-inhibitor
• - Haemodynamically significant aortic or mitral valve stenosis
• - Known renal artery stenosis or kidney transplantation
• - Hypersensitivity to study drug
• - Severe concomitant disease which may interfere with the assessment of the patient, eg, malignancy, as judged by the investigator