Safety, Pharmacokinetics and Pharmacodynamics after single and multiple dosing of AZD5423 in Japanese healthy male subjects

Exclusion Criteria

• - History of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject’s ability to participate in the study
• - History or presence of gastrointestinal, hepatic or renal disease or any other condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs
• - Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the administration of investigational product
• - Any clinically significant abnormalities in clinical chemistry, haematology, urinalysis or physical examination results as judged by the investigators
• - Any positive results on screening for serum hepatitis B surface antigen, hepatitis C antibody, human immunodeficiency virus (HIV) and Syphilis