Addition of Quetiapine in Obsessive Compulsive Disorder - Westenberg study

Inclusion Criteria

• Inclusion Criteria:
• - All patients meet the DSM IV criteria for obsessive-compulsive disorder
• - Y-BOCS score > 16 if obsessions and compulsions
• - Y-BOCS score > 10 if only obsessions
• - Y-BOCS score > 10 if only compulsions
• - Male and female, aged between 18-70 years
• - Female patients of childbearing potential must have a negative pregnancy
• test and use a reliable method of contraception.
• - Written informed consent
• Exclusion Criteria:
• - Presence of any of the following DSM IV conditions; major depression (with a HDRS>15, [17 item]), bipolar disorder, schizophrenia or any other psychotic condition, tic disorder, substance related disorder during the past 6 months, epilepsy, or any structural CNS disorder or stroke within the last year.
• - Evidence of clinically significant and unstable cardiovascular, gastro-intestinal, pulmonary, renal, hepatic, endocrine or haematological disorders, glaucoma, myocardial infarction within the past year, or micturition abnormalities
• - Patients at risk for suicide
• - Multiple serious drug allergies or known allergy for the trial compounds
• - Use of antipsychotics during 6 months before the screening visit
• - Use of any other psychotropic drug during 6 months before the screening visit
• - Cognitive and behavioural treatment 3 months prior to the screening visit
• - Any known contra-indication against citalopram or quetiapine