Ropivacaine versus bupivacaine for spinal anaesthesia in patients undergoing unilateral lower limb surgery

Exclusion Criteria

• - Contraindications to spinal anaesthesia, such as local infections, generalised septicaemia, platelet and clotting factor abnormalities, significant neurological disease with motor or sensory deficit, diagnosed increased intracranial pressure
• - A known history of allergy, sensitivity or any other form of reaction to local anaesthetics of amide type
• - Suspected inability to comply with the study procedures, including language difficulties or medical history and/or concomitant disease, as judged by the investigator
• - Psychiatric history or any other concomitant disease which may lead to unreliability in clinical assessments, as judged by the investigator
• - Significant alcohol, drug or medication abuse, as judged by the investigator
• - Women who are pregnant or lactating or women of child bearing potential who are not practising adequate contraception or have positive urine pregnancy test (a urine Human chorionic gonadotropin [HCG] analysis)
• - Involvement in the planning and conduct of the study (applies to both AstraZeneca staff or staff at the study site)
• - Previous enrolment in the present study
• - Participation in a clinical study during the last 3 months
• - Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subjects’ safety or successful participation in the study.