Study to assess the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of AZD3043

Exclusion Criteria

• - After adequate time (at least 15 minutes) of rest in supine position,
• abnormal vital signs defined as any of the following:·
• - Systolic blood pressure (BP) >140 mm Hg.·
• - Diastolic BP >90 mm Hg.
• - Heart rate <=55 or >85 beats per minute
• - Subjects with compromised airway or respiratory function as evidenced by
• the presence of Class 3 or 4 Airway, Sleep Apnoea, Neck circumference
• > 16.5 inches (42 cm), Asthma, Active or recent (2 weeks) respiratory
• infection, or known chronic respiratory infection, or known chronic
• respirator
• - Lack of a normal phenotype for butyrylcholinesterase (pseudo-cholinesterase)