Study will assess the safety, neutralizing activity and efficacy of AZD3152 in adults with conditions increasing risk of inadequate protective immune response after vaccination and thus are at high risk of developing severe COVID-19 - NOVELLA

Inclusion Criteria

• -Participant must be 18 years of age or older at the time of signing the informed consent.
• -Weight ≥ 45 kg at Visit 1.
• -Participants must satisfy at least 1 of the following risk factors at enrollment:
• 1. Obese, ie, BMI ≥ 30
• 2. Congestive heart failure
• 3. Chronic obstructive pulmonary disease
• 4. Chronic kidney disease
• 5. Intolerant of vaccine
• 6. Immunocompromised state (one of the following risk factors ):
• a) Have cancer
• b) Have solid organ transplant or a hematopoietic stem cell transplant
• c) Are actively taking immunosuppressive medicines
• d) Received chimeric antigen receptor T-cell therapy
• e) Within 1 year of receiving B-cell depleting therapies
• f) Have a moderate or severe primary immunodeficiency
• - Medically stable
• - WOCBP must not be pregnant or lactating and must use a highly effective method of contraception