A Drug Interaction Study of Lanabecestat (LY3314814) and Warfarin in Healthy Participants

Exclusion Criteria

• - Have a history of or current, significant ophthalmic disease, as determined by the investigator or ophthalmologist
• - Have vitiligo or any other clinically significant disorder of skin pigmentation
• as determined by the investigator or dermatologist
• - Have a history or presence of significant bleeding disorders
• - Have a history of gastrointestinal ulcers with hemorrhage
• - Have a personal or family history of coagulation or bleeding disorders or
• reasonable suspicion of vascular malformations
• - Self-reported history of increased bleeding from trauma
• - Have a history of major head trauma (with loss of consciousness) within the
• past year or minor head trauma (without loss of consciousness) within the last
• 3 months prior to screening
• - History of major surgery within 3 months of screening
• - Planned surgery within 14 days after the last day of dosing
• - International Normalized Ratio (INR)/ Prothrombin Time (PT) or activated partial thromboplastin time above the normal reference range at screening
• - Abnormal Protein S antigen and/or Protein C activity as determined by the
• investigator
• - History of deep vein thrombosis and/or pulmonary embolism